Anti Hair Loss


Intensive Reactive Serum
Treatment Shampoo


Anti Hair Loss
(Act Inside Out)



Intensive Anti-Hair Loss Oral Supplement (Drug-Free)


Grey Hair Reverse


Anti-Grey Hair Treatment Shampoo


Hair Fall Is Natural – It Allows New Hair To Grow.

The life cycle of a strand of hair is typically two to five years. Hair follicles cycle through periods of growth (the anagen phase), the longest period of the hair’s life cycle; regression (the catagen phase), where the hair stops actively growing; and rest (the telogen phase), where the hair remains attached to the hair follicle, then falls out to make room for new growth. The anagen phase resumes, and the hair’s life cycle continues.

Catagen Phase (3 weeks)
Normally involves 1% of hair

Telogen Phase (4-5 months)
– Normally involves 10-15% of hair
– In hair loss: Involves more than 20% of hair

Anagen Phase (2-5 years)
– Normally involves 85-90% of hair
– In hair loss: Involves less than 80% of hair

Hair Loss In Males & Females

The Difference


Although the female hormone controls the whole hair, the male-pattern hair loss (AGA = Androgenetic Alopecia) is mainly due to the effects of androgens. AGA is thought to proceed following the transformation of the male hormone testosterone to dihydrotestosterone (DHT) by the enzyme 5α-reductase.

DHT is known as the “bad” male hormone and is recognized by its receptor especially on the surface of dermal papilla, sending a message into the cells telling them “not to make any new hairs”, stopping the division of the hair matrix cells. Thus, hair growth is stopped, the hair cycle migrates from the growth phase to the telogen phase, and hairs fall out. Thus, DHT is considered to be the leading cause of hair loss in males.

Two types of 5α-reductase convert testosterone to DHT:
*Type-I 5α-reductase, present in large quantity in sebaceous glands.
*Type-II 5α-reductase, present in large quantity in the hair papilla.

A recent study clarified that the type-II 5-α reductase is the one that strongly affects male-pattern hair loss. Males with defective type-II 5-α reductase do not experience male-pattern hair loss. The secreted type-II 5α-reductase is mainly expressed in the hair papilla of on the forehead and the top of the head, so men with AGA tend to have thin hair on the forehead and the top of the head.


Estrogen supports the hair’s life cycle through its ability to increase the synthesis of collagen, which gives hair its shine and aids in hair growth.

However, the decrease in estrogen production and its resulting hormonal imbalance can affect the life cycle of hair. This commonly occurs following childbirth, during which there is a temporary increase in hair loss due to the abrupt decrease in estrogen production.

An increase in hair thinning and hair loss is also more common among women in their forties or above, as compared to those in their twenties, when female hormones are at peak secretion levels.

For some women, the presence of female-type AGA is also observed among those experiencing excessive hair loss.

To tackle the time course of estrogen secretion Therefore, a different approach is required to prevent female hair loss and thinning. The important points are to maintain 85% or more of hair in the growing phase, in other words, to maintain cell proliferation, and to prevent age-induced hair follicle contraction and maintain the proper adhesion of the hair roots in the dermis.

堀江義明 Yoshiaki Horie


Medical Director 醫學總監
(Ebisu Beauty Clinic 惠比壽美容クリニック)

Estrogen & Hair Loss

A Different Approach

Preventing hair loss in women requires that they:

1. Maintain 85% or more hair in the anagen (growth) phase, to ensure hair is consistently in regeneration
2. Prevent age-related hair follicle contraction through proper maintenance of the hair roots in the dermis


How To Combat Hair Loss At The Root

The hair bulb consists of keratinocytes dividing to form the hair shaft, the inner sheath, and the outer root sheath.

The dermal papilla, at the base of the bulb, is considered the biological engine of the hair. Growth factors under the influence of the dermal papilla may have a crucial role in the growth and development of hair follicles. IGF1 proteins, responsible for hair bulb matrix formation, help stimulate keratinocytes, guide follicle development and control the hair cycle.

Thus to maintain healthy hair, it is necessary to increase the division rate of hair matrix cells and maintain hair in the anagen phase, and strengthen the attachment ability of the outer root sheath.

The key: Drug-Free supplements with hair growth boosting factors and healthy hair cycle maintenance support.

Although drugs seem to be useful to support hair growth, many consumers worry about the side effects and prefer not to use them. To answer the needs of such consumers, we developed a supplement product that is "safe as food" and does not cause severe side effects, unlike pharmaceutical drugs.

To prevent hair loss due to hormones and aging and to keep the hair healthy, non-pharmaceutical supplements can deliver the required nutrients to the hair for assisting hair growth, and returning the time of hair fallout closer to that in a healthy hair cycle.

堀江義明 Yoshiaki Horie


Medical Director 醫學總監
(Ebisu Beauty Clinic 惠比壽美容クリニック)